TDH

Across TCGA patient cohorts, TDH RNA expression is significantly associated with the protein abundance of many other proteins, with 13,706 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TDH-associated proteins across cancer lineages are RPS6KA5, SEC24A, and MAP1B_S1427. Each is linked with TDH in more than 3 cancer types. Because this analysis shows association rather than direction, both TDH-to-partner and partner-to-TDH results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TDH versus RPS6KA5 in GBM, with a Pearson correlation of 0.41.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TDH→partner) and Y-score (partner→TDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RPS6KA5 →	+0.336	+0.417	.002	.004	3	4
CCRCC	SEC24A →	-0.348	-0.144	<.001	<.001	3	4
LSCC	MAP1B_S1427 →	+1.046	+0.554	.001	<.001	3	4
PDAC	KIF1B_S1454 →	-0.378	-0.406	<.001	.002	3	4
LSCC	SUGP2 →	+0.402	+1.184	<.001	<.001	3	3
LSCC	TNKS1BP1_S1073 →	-0.608	-0.759	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,706 associations by consensus.

TDH vs RPS6KA5 — GBM

Explore this scatter interactively →