TBRG4

Across TCGA patient cohorts, TBRG4 mutation is significantly associated with the RNA expression of many other genes, with 2,393 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBRG4-associated genes across cancer lineages are KNL1, TICRR, and LNPK. Each is linked with TBRG4 in more than 2 cancer types. Because this analysis shows association rather than direction, both TBRG4-to-partner and partner-to-TBRG4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KNL1 grouped by TBRG4-low versus TBRG4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBRG4→partner) and Y-score (partner→TBRG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KNL1 →	+0.579	+2.255	.001	.001	3	3
UCEC	TICRR →	+0.632	+2.256	<.001	.001	3	3
UCEC	LNPK →	+0.671	+2.148	<.001	<.001	3	3
COAD	RNU4-58P →	+0.234	+5.149	<.001	.001	3	3
UCEC	DCP1A →	+0.459	+3.364	.002	.004	3	2
HNSC	MIR302D →	+1.060	+5.069	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,393 associations by consensus.

KNL1 by TBRG4 expression — UCEC

Explore this box plot interactively →