TBRG4

Across TCGA pan-cancer cohorts, TBRG4 RNA differs between tumor and matched normal tissue in 18 of 18 cancer types tested, making tumor–normal expression one of TBRG4’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TBRG4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TBRG4 is over-expressed in tumor.

HNSC, KIRC, and COAD are the cancer types where TBRG4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TBRG4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+1.080	<.001	12	view →
KIRC	All	IV	+0.604	<.001	12	view →
COAD	Female	All	+1.272	<.001	11	view →
KIRP	All	IV	+1.199	<.001	11	view →
STAD	Male	III,IV	+1.315	<.001	10	view →
LUAD	Male	III,IV	+1.406	<.001	9	view →
LIHC	Female	II,III,IV	+1.152	<.001	9	view →
BLCA	Male	All	+0.952	<.001	9	view →
LUSC	Male	All	+1.383	<.001	8	view →
UCEC	All	III,IV	+1.004	<.001	6	view →
BRCA	All	All	+0.458	<.001	6	view →
READ	Female	All	+1.202	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 18 lineages.

TBRG4–HNSC

Open the HNSC breakdown →