TBCC

Across TCGA patient cohorts, TBCC mutation is significantly associated with the RNA expression of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBCC-associated genes across cancer lineages are LINC01256, MIR586, and USP9YP10. Each is linked with TBCC in more than 1 cancer types. Because this analysis shows association rather than direction, both TBCC-to-partner and partner-to-TBCC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01256 grouped by TBCC-low versus TBCC-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBCC→partner) and Y-score (partner→TBCC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LINC01256 →	+0.381	+5.162	<.001	.004	3	2
LGG	MIR586 →	+0.343	+7.977	<.001	.007	3	1
LGG	USP9YP10 →	+0.049	+7.977	<.001	.007	3	1
LGG	RNA5SP421 →	+0.261	+7.977	<.001	.007	3	1
UCEC	GPR75-ASB3 →	+0.117	+3.668	<.001	.005	3	1
UCEC	COPS8P1 →	+0.195	+3.900	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

LINC01256 by TBCC expression — BRCA

Explore this box plot interactively →