TBCC

Across TCGA pan-cancer cohorts, TBCC RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of TBCC’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TBCC RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TBCC is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

KIRC, HNSC, and LIHC are the cancer types where TBCC tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TBCC RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.514	<.001	11	view →
HNSC	All	III,IV	+0.424	<.001	11	view →
LIHC	Female	II,III,IV	+1.349	<.001	9	view →
THCA	All	All	−0.294	<.001	9	view →
KICH	Female	All	−1.177	<.001	7	view →
KIRP	All	IV	+0.892	.002	7	view →
STAD	All	II,III,IV	+0.617	<.001	6	view →
BRCA	All	III,IV	+0.441	<.001	6	view →
CHOL	All	All	+2.393	<.001	5	view →
LUSC	All	All	+0.318	.001	3	view →
UCEC	All	All	+0.266	.039	2	view →
LUAD	All	All	+0.228	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

TBCC–KIRC

Open the KIRC breakdown →