TBC1D19

Across TCGA cell cohorts, TBC1D19 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible TBC1D19-associated genes across cancer lineages are GALNTL5, FAM47B, and CD300LD. Each is linked with TBC1D19 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBC1D19-to-partner and partner-to-TBC1D19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GALNTL5 grouped by TBC1D19-low versus TBC1D19-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D19→partner) and Y-score (partner→TBC1D19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GALNTL5 →	+0.029	+5.415	<.001	.004	3	2
OVARY	FAM47B →	+0.019	+5.196	<.001	.005	3	1
BREAST	CD300LD →	+0.016	+5.169	<.001	.005	3	1
BREAST	KRTAP4-2 →	+0.033	+5.781	<.001	.001	3	1
LUNG_NSCLC_LUAD	IL27 →	+0.385	+3.067	<.001	.005	3	1
LUNG_NSCLC_LUAD	PBOV1 →	+0.021	+3.082	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

GALNTL5 by TBC1D19 expression — SKIN

Explore this box plot interactively →