TBC1D19

Across TCGA pan-cancer cohorts, TBC1D19 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of TBC1D19’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TBC1D19 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TBC1D19 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, THCA, and LIHC are the cancer types where TBC1D19 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TBC1D19 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.608	<.001	11	view →
THCA	Male	III,IV	−0.935	<.001	10	view →
LIHC	Female	II,III,IV	+0.904	<.001	8	view →
KICH	All	II,III,IV	−0.789	<.001	7	view →
CHOL	All	All	+1.653	<.001	3	view →
BRCA	All	IV	+0.964	.047	2	view →
LUSC	All	III,IV	−0.770	.003	2	view →
UCEC	All	All	−0.661	.001	2	view →
KIRP	Male	All	−0.450	.005	2	view →
PRAD	All	All	−0.227	.028	2	view →
COAD	All	II,III,IV	+0.257	.049	1	view →
KIRC	Male	All	−0.213	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

TBC1D19–HNSC

Open the HNSC breakdown →