TAS2R10

Across TCGA cell cohorts, TAS2R10 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TAS2R10-associated genes across cancer lineages are TBC1D3, FAM47C, and SMCP. Each is linked with TAS2R10 in more than 1 cancer types. Because this analysis shows association rather than direction, both TAS2R10-to-partner and partner-to-TAS2R10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBC1D3 grouped by TAS2R10-low versus TAS2R10-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAS2R10→partner) and Y-score (partner→TAS2R10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TBC1D3 →	+0.112	+5.009	<.001	<.001	3	2
SKIN	FAM47C →	+0.006	+4.977	<.001	.007	3	1
CNS	SMCP →	+0.079	+5.321	.007	.005	3	1
LARGE_INTESTINE	CLRN1 →	+0.079	+3.347	<.001	.005	3	1
LARGE_INTESTINE	TRARG1 →	+0.022	+3.345	<.001	.007	3	1
LARGE_INTESTINE	ARGFX →	+0.010	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

TBC1D3 by TAS2R10 expression — LARGE_INTESTINE

Explore this box plot interactively →