STXBP5

Across TCGA patient cohorts, STXBP5 mutation is significantly associated with the RNA expression of many other genes, with 3,457 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STXBP5-associated genes across cancer lineages are ATF4, ENOPH1, and BLOC1S2P1. Each is linked with STXBP5 in more than 3 cancer types. Because this analysis shows association rather than direction, both STXBP5-to-partner and partner-to-STXBP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATF4 grouped by STXBP5-low versus STXBP5-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STXBP5→partner) and Y-score (partner→STXBP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	ATF4 →	+0.459	+3.338	.001	.005	3	4
UCEC	ENOPH1 →	+0.471	+2.896	<.001	<.001	3	4
COAD	BLOC1S2P1 →	+0.156	+3.343	<.001	.007	3	4
UCEC	C14orf119 →	+0.203	+2.409	.009	.002	3	3
UCEC	RCC1 →	+0.404	+2.513	<.001	<.001	3	3
UCEC	NDUFA6 →	+0.369	+2.269	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,457 associations by consensus.

ATF4 by STXBP5 expression — STAD

Explore this box plot interactively →