STXBP5

Across TCGA pan-cancer cohorts, STXBP5 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated STXBP5 data layer compared with 11 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher STXBP5 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated STXBP5 expression acts as an unfavorable survival marker, although some lineages such as LAML and COAD show a favorable association.

ACC, CESC, and KIRP are the cancer types where STXBP5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.340	0.819	<.001	82	view →
CESC	DFS	Median	All	0.419	0.681	.002	78	view →
KIRP	DFS	Median	All	0.788	0.920	<.001	70	view →
LIHC	DFS	Quartile	All	0.429	0.620	.001	57	view →
MESO	OS	Quartile	All	0.359	0.628	.001	49	view →
LUAD	OS	Tertile	All	0.752	0.870	.001	42	view →
OV	DFS	Quartile	III,IV	0.465	0.636	.001	38	view →
LAML	DFS	Quartile	All	0.539	0.165	<.001	36	view →
COAD	OS	Median	All	0.930	0.805	.005	35	view →
DLBC	DFS	Median	All	0.629	1.000	.017	32	view →
READ	OS	Median	II,III,IV	0.866	0.443	.003	27	view →
BRCA	OS	Median	All	0.517	0.644	.004	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

STXBP5–ACC (DFS)

Open the ACC breakdown →