chromosome 14 open reading frame 119Genealiases: []
Q-omics provides the consensus-scored C14orf119 profile across patient tissues and cancer cell-line models. C14orf119 expression is associated with patient survival in 25 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, C14orf119 is differentially expressed in 16, with the highest sampling consensus in HNSC. Additionally, C14orf119 protein abundance shows 19,562 significant protein co-abundance associations, with the highest sampling consensus in PDAC. Together, these results highlight UVM, HNSC, and PDAC as cancer lineages where C14orf119 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for C14orf119 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes C14orf119 survival associations across molecular data types. C14orf119 RNA expression shows survival associations in the most cancer types (25), followed by mutation status (3) and mass-spec protein abundance (5). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible C14orf119 RNA expression–survival associations across cancer types. High C14orf119 expression shows unfavorable associations in UVM, HNSC, LIHC and PAAD, but favorable associations in BRCA and THCA. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UVM as the clearest survival context for C14orf119 RNA expression.
This table summarizes C14orf119 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 16, while mass-spec protein shows differences in 4. The strongest signals are observed in HNSC for RNA and HNSC for protein.
This table ranks reproducible tumor–normal expression differences for C14orf119. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. C14orf119 shows lower tumor expression in KICH and higher tumor expression in HNSC, LIHC, BLCA, BRCA and LUAD. The HNSC box plot shows higher C14orf119 RNA expression in tumor versus normal tissue (log2 FC = +0.882, t-test p < 0.001).
This table shows molecular features associated with C14orf119 in patient tissues and cancer cell lines. In patient samples, C14orf119 shows the broadest associations at the RNA and protein expression levels, with PDAC recurring as the lineage with the largest associated feature set. In cancer cell lines, C14orf119 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BLOOD_Leukemia, while CRISPR and shRNA rows add functional-dependency signals in LUNG_NSCLC_LUAD and LUNG_SCLC.
