STK17B

Across TCGA patient cohorts, STK17B mutation is significantly associated with the RNA expression of many other genes, with 706 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STK17B-associated genes across cancer lineages are HMGB1P13, RNU7-81P, and IGHD6-19. Each is linked with STK17B in more than 1 cancer types. Because this analysis shows association rather than direction, both STK17B-to-partner and partner-to-STK17B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMGB1P13 grouped by STK17B-low versus STK17B-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STK17B→partner) and Y-score (partner→STK17B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	HMGB1P13 →	+0.102	+4.990	.003	.009	3	2
SKCM	RNU7-81P →	+0.355	+4.743	<.001	.005	3	2
SKCM	IGHD6-19 →	+1.512	+3.992	.007	.006	3	2
SKCM	RNU2-72P →	+0.170	+4.282	.001	.009	3	2
UCEC	RNU6-1085P →	+0.304	+2.599	<.001	.003	3	2
COAD	UNGP1 →	+0.129	+4.209	.004	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 706 associations by consensus.

HMGB1P13 by STK17B expression — LUAD

Explore this box plot interactively →