STK17B

Across TCGA pan-cancer cohorts, STK17B RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of STK17B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where STK17B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types STK17B is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

HNSC, KIRC, and KICH are the cancer types where STK17B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in STK17B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.672	<.001	10	view →
KIRC	Male	All	+0.885	<.001	9	view →
KICH	Female	II,III,IV	−2.041	<.001	8	view →
LUSC	Male	II,III,IV	−1.038	<.001	7	view →
STAD	All	II,III,IV	+1.009	.001	6	view →
COAD	Female	All	−1.291	<.001	5	view →
ESCA	All	All	+1.250	<.001	4	view →
CHOL	All	All	+1.778	<.001	3	view →
READ	All	All	−0.802	.016	2	view →
LUAD	Female	II,III,IV	−0.496	.030	2	view →
LIHC	Female	All	+0.586	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

STK17B–HNSC

Open the HNSC breakdown →