STK17B

Across TCGA pan-cancer cohorts, STK17B RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated STK17B data layer compared with 7 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher STK17B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated STK17B expression acts as an unfavorable survival marker, although some lineages such as LUAD and SKCM show a favorable association.

KIRP, UVM, and LUAD are the cancer types where STK17B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	All	0.737	0.916	<.001	125	view →
UVM	DFS	Tertile	All	0.295	0.703	<.001	94	view →
LUAD	DFS	Median	All	0.730	0.596	<.001	77	view →
SKCM	OS	Median	II,III,IV	0.484	0.282	<.001	53	view →
HNSC	DFS	Quartile	II,III,IV	0.723	0.526	.003	31	view →
MESO	OS	Median	All	0.211	0.361	.019	25	view →
PRAD	DFS	Quartile	All	0.970	0.897	.004	18	view →
CESC	OS	Median	All	0.908	0.833	.010	18	view →
CHOL	DFS	Tertile	All	0.695	0.231	.019	12	view →
THYM	OS	Median	All	0.964	0.741	.005	10	view →
DLBC	DFS	Median	All	0.629	1.000	.017	9	view →
THCA	DFS	Median	III,IV	0.850	0.990	.005	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

STK17B–KIRP (DFS)

Open the KIRP breakdown →