STAT3

Across TCGA patient cohorts, STAT3 RNA expression is significantly associated with the RNA expression of many other genes, with 19,735 significant associations in total. KIRP shows the largest number of these associations.

The most reproducible STAT3-associated genes across cancer lineages are STAT5B, RELL1, and BCL9L. Each is linked with STAT3 in more than 33 cancer types. Because this analysis shows association rather than direction, both STAT3-to-partner and partner-to-STAT3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, STAT3 versus STAT5B in ACC, with a Pearson correlation of 0.76.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STAT3→partner) and Y-score (partner→STAT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	STAT5B →	+0.936	+1.134	<.001	<.001	3	34
CHOL	RELL1 →	+1.560	+1.032	<.001	.001	3	34
THYM	BCL9L →	+2.193	+1.075	<.001	<.001	3	34
ACC	GIGYF2 →	+1.207	+1.527	<.001	<.001	3	34
THYM	MICAL3 →	+1.497	+1.122	<.001	<.001	3	34
UVM	MAP3K2 →	+1.069	+0.886	<.001	<.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,735 associations by consensus.

STAT3 vs STAT5B — ACC

Explore this scatter interactively →