STAT3

Across TCGA pan-cancer cohorts, STAT3 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of STAT3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where STAT3 RNA is repressed in tumor relative to normal tissue. In most cancer types STAT3 is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

KICH, STAD, and ESCA are the cancer types where STAT3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in STAT3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	III,IV	−2.108	<.001	11	view →
STAD	All	All	+0.563	.003	4	view →
ESCA	All	All	+0.981	.012	3	view →
HNSC	All	All	+0.363	.014	3	view →
CHOL	All	II,III,IV	+0.870	.033	2	view →
LUSC	All	All	−0.286	.006	2	view →
KIRC	Male	II,III,IV	−0.280	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

STAT3–KICH

Open the KICH breakdown →