STAT3

Across TCGA pan-cancer cohorts, STAT3 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated STAT3 data layer compared with 4 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher STAT3 RNA is associated with better overall survival. In most high-consensus cancer types, elevated STAT3 expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.

SKCM, LGG, and HNSC are the cancer types where STAT3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.393	0.253	<.001	65	view →
LGG	OS	Tertile	All	0.336	0.552	<.001	47	view →
HNSC	DFS	Tertile	All	0.698	0.519	<.001	43	view →
KIRP	DFS	Median	III,IV	0.453	0.709	.021	36	view →
UVM	DFS	Quartile	II,III,IV	0.288	0.763	.008	34	view →
ESCA	DFS	Median	III,IV	0.548	0.285	.001	30	view →
CESC	DFS	Median	III,IV	0.610	0.847	.007	24	view →
STAD	DFS	Quartile	All	0.518	0.843	.003	23	view →
KIRC	DFS	Quartile	All	0.718	0.562	.029	18	view →
UCS	OS	Median	IV	0.752	0.404	.013	18	view →
ACC	DFS	Quartile	All	0.274	0.757	.017	17	view →
SARC	OS	Quartile	All	0.933	0.727	<.001	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

STAT3–SKCM (OS)

Open the SKCM breakdown →