STAT3

Across TCGA patient cohorts, STAT3 protein abundance is significantly associated with the RNA expression of many other genes, with 4,270 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible STAT3-associated genes across cancer lineages are RAB5C, KPNB1, and RETREG3. Each is linked with STAT3 in more than 4 cancer types. Because this analysis shows association rather than direction, both STAT3-to-partner and partner-to-STAT3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, STAT3 versus RAB5C in OV, with a Pearson correlation of 0.54.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STAT3→partner) and Y-score (partner→STAT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RAB5C →	+0.735	+0.333	<.001	<.001	3	5
BRCA	KPNB1 →	+0.586	+0.373	<.001	<.001	3	4
OV	RETREG3 →	+0.624	+0.328	<.001	<.001	3	4
OV	DNAJC7 →	+0.589	+0.427	<.001	<.001	3	4
BRCA	CCDC43 →	+0.554	+0.416	<.001	<.001	3	4
UCEC	BIRC3 →	+0.989	+0.197	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,270 associations by consensus.

STAT3 vs RAB5C — OV

Explore this scatter interactively →