STAT3

Across TCGA patient cohorts, STAT3 mutation is significantly associated with the RNA expression of many other genes, with 2,606 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STAT3-associated genes across cancer lineages are SKA1, EME1, and TONSL. Each is linked with STAT3 in more than 1 cancer types. Because this analysis shows association rather than direction, both STAT3-to-partner and partner-to-STAT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SKA1 grouped by STAT3-low versus STAT3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STAT3→partner) and Y-score (partner→STAT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SKA1 →	+0.793	+2.241	<.001	.006	3	2
SKCM	EME1 →	+0.601	+3.497	.001	.002	3	2
UCEC	TONSL →	+0.415	+1.562	.004	<.001	3	2
UCEC	LSM12 →	+0.409	+1.369	.001	.003	3	2
UCEC	DBF4B →	+0.389	+1.722	<.001	<.001	3	2
UCEC	POLR3K →	+0.309	+2.523	.005	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,606 associations by consensus.

SKA1 by STAT3 expression — SKCM

Explore this box plot interactively →