STAT3

Across TCGA cell cohorts, STAT3 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,278 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible STAT3-associated GO terms across cancer lineages are Interleukin-23-mediated signaling pathway, Positive regulation of purine nucleotide biosynthetic process, and Positive regulation of ATP biosynthetic process. Each is linked with STAT3 in more than 18 cancer types. Because this analysis shows association rather than direction, both STAT3-to-partner and partner-to-STAT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Interleukin-23-mediated signaling pathway grouped by STAT3-low versus STAT3-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (STAT3→partner) and Y-score (partner→STAT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Interleukin-23-mediated signaling pathway →	+0.284	+1.531	<.001	<.001	3	19
LIVER	Positive regulation of purine nucleotide biosynthetic process →	+0.192	+0.992	<.001	.001	3	18
LIVER	Positive regulation of ATP biosynthetic process →	+0.190	+0.936	<.001	.003	3	18
LIVER	Positive regulation of nucleotide biosynthetic process →	+0.192	+0.992	<.001	.001	3	18
OVARY	Negative regulation of primary miRNA processing →	+0.317	+0.997	<.001	<.001	3	16
STOMACH	Postsynapse to nucleus signaling pathway →	+0.180	+1.328	.001	.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,278 associations by consensus.

Interleukin-23-mediated signaling pathway by STAT3 expression — STOMACH

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