STAT3

Across TCGA cell cohorts, STAT3 mutation is significantly associated with the RNA expression of many other genes, with 567 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible STAT3-associated genes across cancer lineages are ACER1, FOXE3, and OXT. Each is linked with STAT3 in more than 1 cancer types. Because this analysis shows association rather than direction, both STAT3-to-partner and partner-to-STAT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACER1 grouped by STAT3-low versus STAT3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STAT3→partner) and Y-score (partner→STAT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACER1 →	+0.086	+2.408	<.001	.004	3	2
LARGE_INTESTINE	FOXE3 →	+0.111	+2.559	<.001	.007	3	2
BLOOD_Lymphoma	OXT →	+0.044	+3.523	<.001	.009	3	1
BLOOD_Lymphoma	OR56A1 →	+0.028	+3.523	.001	.009	3	1
BLOOD_Lymphoma	SLC36A2 →	+0.034	+4.192	<.001	.003	3	1
BLOOD_Lymphoma	OR14A16 →	+0.013	+4.058	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 567 associations by consensus.

ACER1 by STAT3 expression — LARGE_INTESTINE

Explore this box plot interactively →