SRSF4

Across TCGA patient cohorts, SRSF4 mutation is significantly associated with the RNA expression of many other genes, with 1,081 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRSF4-associated genes across cancer lineages are NEGR1-IT1, TRAJ11, and RNU6-131P. Each is linked with SRSF4 in more than 2 cancer types. Because this analysis shows association rather than direction, both SRSF4-to-partner and partner-to-SRSF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NEGR1-IT1 grouped by SRSF4-low versus SRSF4-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRSF4→partner) and Y-score (partner→SRSF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	NEGR1-IT1 →	+0.131	+4.730	<.001	.005	3	3
UCEC	TRAJ11 →	+0.338	+1.591	.003	.007	3	2
LUAD	RNU6-131P →	+0.275	+4.859	<.001	.004	3	2
UCEC	RNA5SP163 →	+0.137	+2.881	<.001	.001	3	2
UCEC	LYPLA1P1 →	+0.030	+2.879	<.001	.007	3	2
PRAD	RBMY2CP →	+0.044	+7.939	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,081 associations by consensus.

NEGR1-IT1 by SRSF4 expression — LUAD

Explore this box plot interactively →