SRSF4

Across TCGA pan-cancer cohorts, SRSF4 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of SRSF4’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SRSF4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SRSF4 is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

HNSC, KIRC, and KICH are the cancer types where SRSF4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SRSF4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.720	<.001	12	view →
KIRC	Female	All	+0.534	<.001	11	view →
KICH	Female	All	−1.291	<.001	7	view →
LIHC	Female	III,IV	+0.766	<.001	6	view →
BLCA	All	All	+0.287	.018	5	view →
STAD	All	II,III,IV	+0.599	.001	4	view →
BRCA	Female	All	−0.182	<.001	4	view →
CHOL	Male	All	+1.443	<.001	3	view →
KIRP	All	IV	+0.754	.003	2	view →
ESCA	All	All	+0.471	.009	2	view →
UCEC	All	All	−0.369	.006	2	view →
PRAD	All	All	−0.216	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

SRSF4–HNSC

Open the HNSC breakdown →