SRRT

Across TCGA patient cohorts, SRRT mutation is significantly associated with the RNA expression of many other genes, with 3,369 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRRT-associated genes across cancer lineages are LINC01810, TRIM64EP, and LINC02563. Each is linked with SRRT in more than 2 cancer types. Because this analysis shows association rather than direction, both SRRT-to-partner and partner-to-SRRT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01810 grouped by SRRT-low versus SRRT-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRRT→partner) and Y-score (partner→SRRT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LINC01810 →	+0.107	+6.467	<.001	<.001	3	3
PRAD	TRIM64EP →	+0.068	+7.939	<.001	.008	3	3
LUAD	LINC02563 →	+0.137	+4.481	<.001	.009	3	2
LGG	RN7SKP214 →	+0.198	+5.127	<.001	.001	3	2
UCEC	CCDC163 →	+0.390	+2.031	<.001	.001	3	2
UCEC	PTP4A2P1 →	+0.312	+1.377	.002	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,369 associations by consensus.

LINC01810 by SRRT expression — BRCA

Explore this box plot interactively →