SRRT

Across TCGA pan-cancer cohorts, SRRT RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated SRRT data layer compared with 6 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher SRRT RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SRRT expression acts as an unfavorable survival marker, although some lineages such as THYM and SCLC show a favorable association.

UVM, KICH, and ACC are the cancer types where SRRT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.417	0.804	<.001	110	view →
KICH	DFS	Quartile	II,III,IV	0.261	0.950	<.001	104	view →
ACC	DFS	Median	All	0.339	0.819	<.001	101	view →
LIHC	OS	Median	All	0.702	0.842	<.001	88	view →
KIRC	DFS	Quartile	II,III,IV	0.389	0.645	.001	68	view →
LGG	DFS	Median	All	0.638	0.830	<.001	54	view →
THYM	DFS	Quartile	All	0.965	0.375	<.001	35	view →
KIRP	DFS	Median	II,III,IV	0.279	0.708	.009	27	view →
COAD	DFS	Tertile	All	0.734	0.846	.005	23	view →
PRAD	DFS	Quartile	All	0.686	0.885	.001	22	view →
MESO	DFS	Quartile	All	0.288	0.786	.006	18	view →
SCLC	DFS	Quartile	II,III,IV	0.806	0.156	.024	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

SRRT–UVM (DFS)

Open the UVM breakdown →