SPRTN

Across TCGA patient cohorts, SPRTN mutation is significantly associated with the RNA expression of many other genes, with 3,730 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPRTN-associated genes across cancer lineages are OR8J1, ARF4P3, and HMGB1P22. Each is linked with SPRTN in more than 1 cancer types. Because this analysis shows association rather than direction, both SPRTN-to-partner and partner-to-SPRTN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR8J1 grouped by SPRTN-low versus SPRTN-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRTN→partner) and Y-score (partner→SPRTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	OR8J1 →	+0.053	+6.711	.003	<.001	3	2
BRCA	ARF4P3 →	+0.104	+4.995	<.001	.009	3	2
SKCM	HMGB1P22 →	+0.281	+5.037	<.001	.009	3	2
SKCM	RNU7-179P →	+0.544	+5.037	<.001	.009	3	2
SKCM	GARS1P1 →	+0.067	+4.979	<.001	.009	3	2
SKCM	MTND1P27 →	+0.042	+5.224	.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,730 associations by consensus.

OR8J1 by SPRTN expression — BRCA

Explore this box plot interactively →