SPRTN

Across TCGA pan-cancer cohorts, SPRTN RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated SPRTN data layer compared with 4 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher SPRTN RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SPRTN expression acts as an unfavorable survival marker, although some lineages such as KIRC and LUSC show a favorable association.

ACC, KIRC, and LUSC are the cancer types where SPRTN RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.401	0.756	<.001	130	view →
KIRC	OS	Quartile	All	0.854	0.736	<.001	56	view →
LUSC	DFS	Tertile	All	0.790	0.686	.003	43	view →
UVM	DFS	Quartile	III,IV	0.197	0.832	.001	41	view →
READ	DFS	Quartile	III,IV	0.469	0.856	.002	24	view →
KICH	DFS	Median	II,III,IV	0.588	0.917	.008	24	view →
GBM	DFS	Tertile	All	0.445	0.168	.001	21	view →
LIHC	OS	Quartile	All	0.667	0.870	<.001	18	view →
KIRP	DFS	Median	All	0.883	0.935	.024	17	view →
LGG	OS	Median	All	0.761	0.899	.001	17	view →
BLCA	DFS	Median	All	0.170	0.489	.013	15	view →
MESO	OS	Median	IV	0.344	0.811	.004	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

SPRTN–ACC (DFS)

Open the ACC breakdown →