SPRTN

Across TCGA pan-cancer cohorts, SPRTN RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SPRTN’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where SPRTN RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SPRTN is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

BLCA, HNSC, and THCA are the cancer types where SPRTN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPRTN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	IV	+0.524	<.001	12	view →
HNSC	Male	III,IV	+0.868	<.001	11	view →
THCA	Male	III,IV	−0.831	<.001	10	view →
LIHC	Male	II,III,IV	+0.969	<.001	9	view →
KICH	Female	All	−1.078	<.001	8	view →
STAD	Male	II,III,IV	+0.725	<.001	8	view →
LUAD	Male	II,III,IV	+0.714	<.001	8	view →
COAD	Female	II,III,IV	+0.485	<.001	8	view →
LUSC	Male	All	+0.749	<.001	7	view →
BRCA	All	II,III,IV	+0.512	<.001	6	view →
UCEC	All	All	+0.421	.015	6	view →
CHOL	Male	All	+1.783	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SPRTN–BLCA

Open the BLCA breakdown →