Across TCGA patient cohorts, SPRR2B mutation is significantly associated with the RNA expression of many other genes, with 76 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible SPRR2B-associated genes across cancer lineages are OR2T1, RNU6-1106P, and RNU6-351P. Each is linked with SPRR2B in more than 1 cancer types. Because this analysis shows association rather than direction, both SPRR2B-to-partner and partner-to-SPRR2B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPRR2B→partner) and Y-score (partner→SPRR2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	OR2T1 →	+0.059	+4.352	.003	.008	3	2
COAD	RNU6-1106P →	+0.271	+7.741	<.001	.009	3	1
COAD	RNU6-351P →	+0.284	+7.741	<.001	.009	3	1
SKCM	NME1P1 →	+0.047	+4.025	<.001	.007	3	1
SKCM	RNU1-80P →	+0.141	+3.233	<.001	.005	3	1
SKCM	SNRPGP3 →	+0.237	+2.517	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 76 associations by consensus.

Exploration

SPRR2B survival (RNA) · tumor vs normal (RNA) · all SPRR2B data types