Across TCGA pan-cancer cohorts, SPRR2B RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of SPRR2B’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where SPRR2B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SPRR2B is over-expressed in tumor, although a few such as BRCA and LUAD show the opposite, repressed pattern.

LUSC, BRCA, and LUAD are the cancer types where SPRR2B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPRR2B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Male	All	+2.207	<.001	6	view →
BRCA	All	III,IV	−0.201	<.001	3	view →
LUAD	Female	All	−0.114	.008	1	view →
READ	All	All	−0.090	.009	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: SPRR2B RNA expression & survival · all SPRR2B data types