Q-omics provides the consensus-scored SPDYE8 profile across patient tissues and cancer cell-line models. SPDYE8 expression is associated with patient survival in 4 of 34 cancer types, with the highest sampling consensus in LUSC. Additionally, SPDYE8 RNA expression shows 117 significant gene co-expression associations, with the highest sampling consensus in LUAD. Together, these results highlight LUSC, and LUAD as cancer lineages where SPDYE8 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.

Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.

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Survival associations

This table summarizes SPDYE8 survival associations across molecular data types. SPDYE8 RNA expression shows survival associations in the most cancer types (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.

SPDYE8 data type	Survival analysis	Lineage consensus	Lineage of highest sampling consensus
RNA	Kaplan–Meier	4	LUSC (36)	view →

This table ranks reproducible SPDYE8 RNA expression–survival associations across cancer types. High SPDYE8 expression shows unfavorable associations in LUSC, STAD and SARC, but favorable associations in GBM. The LUSC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify LUSC as the clearest survival context for SPDYE8 RNA expression.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Tertile	All	0.124	0.776	<.001	36	view →
STAD	DFS	Tertile	III,IV	0.089	0.590	<.001	18	view →
SARC	OS	Tertile	All	0.162	0.767	.002	18	view →
GBM	DFS	Tertile	All	0.584	0.246	.044	3	view →

Pink = unfavorable, green = favorable. all 4 lineages →

SPDYE8-LUSC (OS)

Kaplan–Meier survival curve for SPDYE8 RNA expression in LUSC: high vs low expression groups.

Explore this curve interactively →

Cross-omics associations

This table shows molecular features associated with SPDYE8 in patient tissues and cancer cell lines. In patient samples, SPDYE8 shows the broadest associations at the RNA and protein expression levels, with LUAD recurring as the lineage with the largest associated feature set.

Associated data type	Strength (# associated data)	Lineage of highest associated data
▼RNA
RNA	117	LUAD (41)	view →
Mutation	81	BRCA (24)	view →