SPDYE8

Across TCGA pan-cancer cohorts, SPDYE8 RNA is linked to patient survival in 4 of 34 cancer types, making it the most broadly survival-associated SPDYE8 data layer.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher SPDYE8 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SPDYE8 expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

LUSC, SARC, and STAD are the cancer types where SPDYE8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Tertile	All	0.124	0.776	<.001	36	view →
SARC	OS	Tertile	All	0.162	0.767	.002	18	view →
STAD	DFS	Tertile	III,IV	0.089	0.590	<.001	18	view →
GBM	DFS	Tertile	All	0.584	0.246	.044	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SPDYE8–LUSC (OS)

Open the LUSC breakdown →