SPDYE7P

Across TCGA patient cohorts, SPDYE7P mutation is significantly associated with the RNA expression of many other genes, with 450 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPDYE7P-associated genes across cancer lineages are IGHVII-28-1, EIF3JP1, and RN7SL788P. Each is linked with SPDYE7P in more than 2 cancer types. Because this analysis shows association rather than direction, both SPDYE7P-to-partner and partner-to-SPDYE7P results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGHVII-28-1 grouped by SPDYE7P-low versus SPDYE7P-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPDYE7P→partner) and Y-score (partner→SPDYE7P) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	IGHVII-28-1 →	+0.936	+6.144	<.001	.001	3	3
UCEC	EIF3JP1 →	+0.226	+2.883	<.001	<.001	3	3
HNSC	RN7SL788P →	+0.265	+4.398	<.001	.006	3	3
CESC	NCKAP1P1 →	+0.040	+5.201	<.001	.007	3	2
CESC	RN7SKP77 →	+0.164	+6.837	<.001	<.001	3	2
UCEC	NCOA4P1 →	+0.097	+2.917	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 450 associations by consensus.

IGHVII-28-1 by SPDYE7P expression — CESC

Explore this box plot interactively →