SPDYE7P

Across TCGA pan-cancer cohorts, SPDYE7P RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated SPDYE7P data layer compared with 7 for mutation status.

The strongest signal is observed in pancreatic adenocarcinoma (PAAD), where higher SPDYE7P RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SPDYE7P expression acts as an unfavorable survival marker, although some lineages such as BRCA and SKCM show a favorable association.

PAAD, UVM, and LUSC are the cancer types where SPDYE7P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PAAD	DFS	Tertile	All	0.328	0.530	.003	50	view →
UVM	OS	Quartile	III,IV	0.382	0.914	.002	35	view →
LUSC	DFS	Tertile	III,IV	0.231	0.716	.014	28	view →
SARC	OS	Tertile	All	0.386	0.682	.001	24	view →
ACC	OS	Quartile	All	0.231	0.802	.001	23	view →
KICH	OS	Tertile	All	0.602	1.000	.008	15	view →
BRCA	OS	Tertile	III,IV	0.721	0.457	.016	11	view →
SKCM	DFS	Tertile	All	0.245	0.170	.023	9	view →
THYM	DFS	Median	III,IV	1.000	0.494	.015	9	view →
ESCA	OS	Tertile	III,IV	0.624	0.341	.005	6	view →
MESO	DFS	Quartile	III,IV	0.124	0.514	.042	6	view →
LIHC	DFS	Tertile	II,III,IV	0.546	0.357	.032	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

SPDYE7P–PAAD (DFS)

Open the PAAD breakdown →