SPATA6L

Across TCGA patient cohorts, SPATA6L mutation is significantly associated with the RNA expression of many other genes, with 2,853 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPATA6L-associated genes across cancer lineages are LIN28AP2, RPL36P18, and MT-TA. Each is linked with SPATA6L in more than 1 cancer types. Because this analysis shows association rather than direction, both SPATA6L-to-partner and partner-to-SPATA6L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LIN28AP2 grouped by SPATA6L-low versus SPATA6L-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA6L→partner) and Y-score (partner→SPATA6L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LIN28AP2 →	+0.112	+4.251	<.001	.008	3	2
COAD	RPL36P18 →	+0.419	+3.387	<.001	.007	3	2
BRCA	MT-TA →	+0.579	+5.259	<.001	.007	3	2
SKCM	HINT1P2 →	+0.103	+4.021	<.001	.002	3	2
UCEC	MIR4692 →	+0.240	+2.951	<.001	.007	3	2
UCEC	IQCF6 →	+0.262	+1.865	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,853 associations by consensus.

LIN28AP2 by SPATA6L expression — COAD

Explore this box plot interactively →