SPATA6L

Across TCGA pan-cancer cohorts, SPATA6L RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of SPATA6L’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where SPATA6L RNA is repressed in tumor relative to normal tissue. In most cancer types SPATA6L is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

KICH, COAD, and LUSC are the cancer types where SPATA6L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPATA6L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−0.940	<.001	10	view →
COAD	Male	All	+0.672	<.001	9	view →
LUSC	All	III,IV	−1.056	<.001	8	view →
KIRP	Male	All	+0.460	.003	8	view →
LUAD	Female	III,IV	−0.652	<.001	6	view →
BRCA	All	All	−0.194	.021	4	view →
CHOL	All	All	+1.020	<.001	3	view →
READ	All	All	+0.688	.007	2	view →
STAD	Male	All	+0.421	.019	2	view →
LIHC	Male	All	−0.317	<.001	2	view →
KIRC	Male	All	+0.217	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

SPATA6L–KICH

Open the KICH breakdown →