SPATA48

Across TCGA patient cohorts, SPATA48 mutation is significantly associated with the RNA expression of many other genes, with 741 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPATA48-associated genes across cancer lineages are RN7SL248P, ZYXP1, and MIR519D. Each is linked with SPATA48 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPATA48-to-partner and partner-to-SPATA48 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by SPATA48-low versus SPATA48-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA48→partner) and Y-score (partner→SPATA48) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL248P →	+0.039	+2.915	.004	.007	3	2
UCEC	ZYXP1 →	+0.103	+3.069	.009	.005	3	2
UCEC	MIR519D →	+0.279	+2.174	.001	.003	3	2
UCEC	KDM5C-IT1 →	+0.140	+2.461	.009	<.001	3	2
COAD	RNU6-633P →	+0.819	+3.789	<.001	.004	3	1
COAD	MIR199A2 →	+0.875	+3.833	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 741 associations by consensus.

RN7SL248P by SPATA48 expression — UCEC

Explore this box plot interactively →