SPATA48

Across TCGA pan-cancer cohorts, SPATA48 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated SPATA48 data layer compared with 3 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher SPATA48 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SPATA48 expression acts as an unfavorable survival marker, although some lineages such as ACC and HNSC show a favorable association.

UVM, ACC, and HNSC are the cancer types where SPATA48 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	II,III,IV	0.275	0.735	<.001	81	view →
ACC	OS	Tertile	All	0.945	0.727	.003	69	view →
HNSC	DFS	Tertile	All	0.720	0.584	.010	42	view →
COAD	OS	Tertile	IV	0.056	0.659	<.001	36	view →
LAML	DFS	Quartile	All	0.279	0.530	<.001	36	view →
STAD	DFS	Quartile	III,IV	0.780	0.509	.004	34	view →
ESCA	DFS	Tertile	All	0.157	0.706	.031	18	view →
THCA	OS	Tertile	All	0.937	0.987	.006	18	view →
SCLC	DFS	Tertile	III,IV	0.137	0.756	.025	18	view →
LIHC	DFS	Tertile	II,III,IV	0.155	0.474	.022	18	view →
BRCA	DFS	Tertile	All	0.654	0.503	.011	18	view →
CESC	DFS	Tertile	All	0.953	0.721	.021	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

SPATA48–UVM (OS)

Open the UVM breakdown →