SPATA48

Across TCGA pan-cancer cohorts, SPATA48 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of SPATA48’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SPATA48 RNA is repressed in tumor relative to normal tissue. In most cancer types SPATA48 is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

THCA, COAD, and BRCA are the cancer types where SPATA48 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPATA48 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−0.035	.013	2	view →
COAD	All	II,III,IV	−0.024	.029	2	view →
BRCA	All	III,IV	−0.006	.041	2	view →
KIRC	All	All	+0.004	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

SPATA48–THCA

Open the THCA breakdown →