SPATA48

Across TCGA cell cohorts, SPATA48 mutation is significantly associated with the RNA expression of many other genes, with 51 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible SPATA48-associated genes across cancer lineages are PNLIPRP1, NAT8B, and ZNF735. Each is linked with SPATA48 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPATA48-to-partner and partner-to-SPATA48 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PNLIPRP1 grouped by SPATA48-low versus SPATA48-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA48→partner) and Y-score (partner→SPATA48) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PNLIPRP1 →	+0.039	+3.242	.005	.003	3	2
LARGE_INTESTINE	NAT8B →	+1.327	+3.667	<.001	.003	3	2
LUNG_SCLC	ZNF735 →	+0.048	+4.044	<.001	.009	3	2
LUNG_NSCLC_LUAD	HAO1 →	+0.147	+2.958	.002	.004	3	1
LUNG_NSCLC_LUAD	UNC80 →	+0.098	+3.482	<.001	.008	3	1
LUNG_NSCLC_LUAD	SPHKAP →	+0.074	+3.145	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

PNLIPRP1 by SPATA48 expression — LARGE_INTESTINE

Explore this box plot interactively →