SPATA25

Across TCGA patient cohorts, SPATA25 mutation is significantly associated with the RNA expression of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPATA25-associated genes across cancer lineages are PRELID3BP10, RNA5SP183, and DEFB107B. Each is linked with SPATA25 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPATA25-to-partner and partner-to-SPATA25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRELID3BP10 grouped by SPATA25-low versus SPATA25-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPATA25→partner) and Y-score (partner→SPATA25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRELID3BP10 →	+0.300	+3.782	.001	.005	3	2
STAD	RNA5SP183 →	+0.387	+4.981	.002	.002	3	2
HNSC	DEFB107B →	+0.239	+7.954	<.001	.008	3	1
UCEC	TRAJ37 →	+1.093	+3.496	<.001	.005	3	1
SKCM	HNRNPA3P8 →	+0.085	+3.811	.005	.009	3	1
UCEC	RNU6-495P →	+0.623	+3.599	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

PRELID3BP10 by SPATA25 expression — UCEC

Explore this box plot interactively →