SPATA25

Across TCGA pan-cancer cohorts, SPATA25 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated SPATA25 data layer compared with 2 for mutation status.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher SPATA25 RNA is associated with better overall survival. In most high-consensus cancer types, elevated SPATA25 expression acts as an unfavorable survival marker, although some lineages such as READ and UCS show a favorable association.

READ, UCS, and UVM are the cancer types where SPATA25 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	OS	Median	II,III,IV	0.889	0.283	<.001	91	view →
UCS	OS	Quartile	II,III,IV	0.717	0.178	.002	60	view →
UVM	DFS	Quartile	III,IV	0.223	0.900	.002	53	view →
KIRC	DFS	Quartile	III,IV	0.275	0.604	.002	46	view →
HNSC	DFS	Quartile	IV	0.778	0.558	.001	41	view →
THCA	OS	Quartile	II,III,IV	0.868	1.000	<.001	40	view →
UCEC	DFS	Quartile	II,III,IV	0.623	0.831	.008	30	view →
LIHC	DFS	Tertile	II,III,IV	0.282	0.532	.002	25	view →
PAAD	DFS	Quartile	All	0.594	0.383	.007	25	view →
COAD	OS	Quartile	II,III,IV	0.833	0.926	.010	25	view →
ESCA	OS	Quartile	All	0.376	0.609	.017	24	view →
PRAD	DFS	Median	All	0.725	0.831	.002	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

SPATA25–READ (OS)

Open the READ breakdown →