Across TCGA cell cohorts, SPANXN3 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible SPANXN3-associated genes across cancer lineages are LCE1F, ADCY8, and ACER1. Each is linked with SPANXN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPANXN3-to-partner and partner-to-SPANXN3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPANXN3→partner) and Y-score (partner→SPANXN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	LCE1F →	+0.143	+5.643	<.001	.002	3	2
LARGE_INTESTINE	ADCY8 →	+0.754	+3.658	<.001	.005	3	1
LARGE_INTESTINE	ACER1 →	+0.105	+4.145	<.001	.001	3	1
LUNG_SCLC	FAM47B →	+0.016	+5.029	<.001	.006	3	1
LUNG_SCLC	LCE1C →	+0.896	+5.643	<.001	.002	3	1
LUNG_SCLC	PRAMEF11 →	+0.026	+5.029	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

SPANXN3 survival (RNA) · tumor vs normal (RNA) · all SPANXN3 data types