Across TCGA pan-cancer cohorts, SPANXN3 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of SPANXN3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SPANXN3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SPANXN3 is over-expressed in tumor.

HNSC, BRCA, and KIRP are the cancer types where SPANXN3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPANXN3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	All	+0.087	.008	6	view →
BRCA	All	II,III,IV	+0.082	<.001	6	view →
KIRP	All	III,IV	+0.132	.039	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: SPANXN3 RNA expression & survival · all SPANXN3 data types