SOX2

Across TCGA patient cohorts, SOX2 RNA expression is significantly associated with the RNA expression of many other genes, with 14,718 significant associations in total. TGCT shows the largest number of these associations.

The most reproducible SOX2-associated genes across cancer lineages are SOX2-OT, PTPRZ1, and SOX21-AS1. Each is linked with SOX2 in more than 25 cancer types. Because this analysis shows association rather than direction, both SOX2-to-partner and partner-to-SOX2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SOX2 versus SOX2-OT in LUSC, with a Pearson correlation of 0.72.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOX2→partner) and Y-score (partner→SOX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	SOX2-OT →	+2.250	+3.274	<.001	<.001	3	26
TGCT	PTPRZ1 →	+3.617	+5.826	<.001	<.001	3	22
LUSC	SOX21-AS1 →	+1.918	+2.874	<.001	<.001	3	20
LUSC	COLGALT2 →	+2.034	+2.782	<.001	<.001	3	19
LGG	CHST9 →	+1.247	+0.690	<.001	<.001	3	19
LUSC	SOX21 →	+2.832	+3.116	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,718 associations by consensus.

SOX2 vs SOX2-OT — LUSC

Explore this scatter interactively →