SOX2

Across TCGA pan-cancer cohorts, SOX2 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of SOX2’s most consistent transcriptional readouts.

The strongest signal is observed in stomach adenocarcinoma (STAD), where SOX2 RNA is repressed in tumor relative to normal tissue. In most cancer types SOX2 is over-expressed in tumor, although a few such as STAD and PRAD show the opposite, repressed pattern.

STAD, LUSC, and BRCA are the cancer types where SOX2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SOX2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
STAD	All	II,III,IV	−1.754	<.001	10	view →
LUSC	Female	All	+4.611	<.001	7	view →
BRCA	All	II,III,IV	+0.550	<.001	6	view →
PRAD	All	All	−0.771	.001	2	view →
LIHC	All	All	+0.273	.007	2	view →
KIRC	All	All	−0.100	.024	2	view →
KICH	Male	IV	−0.073	.025	2	view →
READ	Female	All	−1.380	.023	1	view →
HNSC	Male	All	+1.135	.040	1	view →
THCA	Female	All	−0.048	.019	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

SOX2–STAD

Open the STAD breakdown →