SOX2

Across TCGA pan-cancer cohorts, SOX2 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated SOX2 data layer compared with 1 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SOX2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SOX2 expression acts as an unfavorable survival marker, although some lineages such as LUSC and GBM show a favorable association.

KIRC, LUSC, and BLCA are the cancer types where SOX2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.510	0.732	<.001	124	view →
LUSC	OS	Quartile	All	0.742	0.562	<.001	39	view →
BLCA	DFS	Median	II,III,IV	0.560	0.671	.006	32	view →
KIRP	OS	Quartile	All	0.360	0.738	.008	32	view →
GBM	DFS	Median	All	0.374	0.201	.009	20	view →
UCEC	DFS	Tertile	III,IV	0.704	0.890	.014	18	view →
HNSC	OS	Quartile	All	0.842	0.690	.007	16	view →
UVM	DFS	Tertile	All	0.403	0.905	.005	14	view →
ACC	DFS	Median	II,III,IV	0.404	0.683	.018	10	view →
CESC	OS	Quartile	All	0.937	0.815	.016	10	view →
THCA	DFS	Tertile	All	0.984	0.913	.003	10	view →
STAD	OS	Tertile	IV	0.562	0.161	.014	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

SOX2–KIRC (DFS)

Open the KIRC breakdown →