SNORD115-40

Across TCGA patient cohorts, SNORD115-40 mutation is significantly associated with the RNA expression of many other genes, with 96 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible SNORD115-40-associated genes across cancer lineages are POMPP1, RNU6-871P, and RNA5SP249. Each is linked with SNORD115-40 in more than 1 cancer types. Because this analysis shows association rather than direction, both SNORD115-40-to-partner and partner-to-SNORD115-40 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POMPP1 grouped by SNORD115-40-low versus SNORD115-40-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SNORD115-40→partner) and Y-score (partner→SNORD115-40) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	POMPP1 →	+0.203	+4.621	.004	.008	3	1
UCEC	RNU6-871P →	+0.678	+5.453	<.001	.002	3	1
UCEC	RNA5SP249 →	+0.860	+6.470	<.001	<.001	3	1
SKCM	OR2K2 →	+0.074	+3.701	.004	.001	3	1
SKCM	OR9I1 →	+0.021	+4.302	<.001	.007	3	1
SKCM	XIAPP3 →	+0.142	+3.551	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 96 associations by consensus.

POMPP1 by SNORD115-40 expression — UCEC

Explore this box plot interactively →