X-linked inhibitor of apoptosis pseudogene 3Genealiases: []
Q-omics provides the consensus-scored XIAPP3 profile across patient tissues and cancer cell-line models. XIAPP3 expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in THCA. Among the 18 cancer types available for tumor–normal comparison, XIAPP3 is differentially expressed in 10, with the highest sampling consensus in HNSC. Additionally, XIAPP3 RNA expression shows 15,023 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight THCA, HNSC, and THYM as cancer lineages where XIAPP3 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for XIAPP3 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes XIAPP3 survival associations across molecular data types. XIAPP3 RNA expression shows survival associations in the most cancer types (22). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible XIAPP3 RNA expression–survival associations across cancer types. High XIAPP3 expression shows unfavorable associations in THCA, MESO, KIRP, UCEC, LGG and PCPG. The THCA Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify THCA as the clearest survival context for XIAPP3 RNA expression.
This table summarizes XIAPP3 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10. The strongest signals are observed in HNSC for RNA.
This table ranks reproducible tumor–normal expression differences for XIAPP3. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. XIAPP3 shows higher tumor expression in HNSC, LUSC, KICH, UCEC, LIHC and BLCA. The HNSC box plot shows higher XIAPP3 RNA expression in tumor versus normal tissue (log2 FC = +0.061, t-test p < 0.001).
This table shows molecular features associated with XIAPP3 in patient tissues and cancer cell lines. In patient samples, XIAPP3 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set.
