XIAPP3

Across TCGA pan-cancer cohorts, XIAPP3 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated XIAPP3 data layer.

The strongest signal is observed in thyroid carcinoma (THCA), where higher XIAPP3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated XIAPP3 expression acts as an unfavorable survival marker, although some lineages such as BLCA and GBM show a favorable association.

THCA, MESO, and KIRP are the cancer types where XIAPP3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	DFS	Tertile	IV	0.621	0.927	<.001	90	view →
MESO	OS	Median	All	0.201	0.694	<.001	87	view →
KIRP	OS	Tertile	All	0.287	0.738	<.001	56	view →
UCEC	OS	Tertile	All	0.522	0.713	<.001	48	view →
LGG	OS	Tertile	All	0.339	0.487	<.001	45	view →
PCPG	OS	Tertile	All	0.831	0.993	<.001	42	view →
BLCA	OS	Median	IV	0.370	0.206	.014	35	view →
CHOL	OS	Median	III,IV	0.286	1.000	.008	21	view →
ACC	OS	Median	All	0.282	0.768	<.001	20	view →
PAAD	OS	Median	All	0.297	0.498	.009	15	view →
GBM	DFS	Quartile	All	0.517	0.198	.001	15	view →
STAD	DFS	Tertile	II,III,IV	0.496	0.687	.010	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

XIAPP3–THCA (DFS)

Open the THCA breakdown →